What is Atherosclerosis

Cholesterol comes to the arterial contend in the form of LDL particles, which git pass through and through the intercellular gaps between the intima lining cells (What). Cholesterol is released from the LDL particles and attracts macrophages, which touch on it into HDL particles to avoid becoming foam cells and dying. A unchew satisfactory protective cap forms between the fatty deposits and the arterial intima. The atheroma produces enzymes which stupefy enlargement of the artery over time to compensate for the wasted thickness of the atheroma and prevent stenosis. This can result in aneurysm formation. This process can take place over decades without producing symptoms.

If the ropey cap over the atheroma pauses, atheroma tissue fragments atomic number 18 released into the course stream, promoting blood change state formation, leading to a temporary covering of the rupture and some narrowing of the artery (What). This can be a repetitive event over time, and may lead to stark(a) arterial stenosis. Seventy-fiver percent stenosis is the severity at which fall out episodes of angina and abnormal reactions to a stress test occur.

coronary artery disease begins early in life, sometimes in late childhood, hardly causes no symptoms and is not recognized by any symptomatic tests in the early stages (What). It usually becomes symptomatic when it interferes with the coronary or cerebral circulation. Atherosclerosis is the major underlying cause o

Role of JNK/SAPK Pathway in LXR signaling

LXR-RXR heterodimers are able to regulate ABCA1 and other genes which are involved in cholesterol homeostasis, and synthetic agonists of LXR and RXR have been shown to reduce atherosclerosis in mice (Li and Glass). LXR-? also induces SREBP-1c, which positively regulates genes involved in fatty astringent and triglyceride biosynthesis in the liver. LXR-? specific agonists may be able to retain antiatherogenic properties without also raising triglycerides.

If a blood clot (thrombus) forms inside a cerebral artery narrowed by atherosclerosis, it cuts off the blood publish to a certain compass of the brain and a stroke may occur (What). just about 75 percent of strokes in industrialized nations are thrombotic strokes; the symmetry are hemorrhagic strokes. If atherosclerosis narrows the arteries supplying blood to the bowels, group AB angina occurs, and sudden, complete blockage of the blood supply to the intestine can cause bowel infarction. In the extremities, atherosclerosis can narrow the major arterial supply to the legs, the femoral and popliteal arteries. The reduced blood flow results in cramping leg hurt during exercise, which is known as intermittent claudication. Severely compromised blood supply to the legs leads to pale or cyanotic, cold legs which eventually may flummox gangrene. Aortic aneurysms and renal artery stenosis may also occur due to atherosclerosis.

Watanabe, T., Hirata, M., Yoshikawa, Y., Nagafuchi, Y., Toyoshima, H., & Watanabe, T. "Role of macrophages in atherosclerosis: incidental observations of cholesterol-induced rabbit aortic lesion by the immunoperoxidase technique using monoclonal antibody antimacrophage antibody." Laboratory Investigation. 5391(1985): 80-90.

"Advanced Molecular Genetics-Biology 566." 2005. 26 June 2005.

Order your essay at Orderessay and get a 100% original and high-quality custom paper within the required time frame.